In-vivo holmium laser angioplasty

Karl Konstantin Haase M.D.; Stefan Hassenstein M.D.; Hartmut Hanke M.D.; Sybille Hanke M.D.; Martin Oberhoff M.D.; Karl R. Karsch M.D.

doi:10.1117/12.137291

28 August 1992 In-vivo holmium laser angioplasty

Karl Konstantin Haase M.D., Stefan Hassenstein M.D., Hartmut Hanke M.D., Sybille Hanke M.D., Martin Oberhoff M.D., Karl R. Karsch M.D.

Author Affiliations +

Proceedings Volume 1642, Diagnostic and Therapeutic Cardiovascular Interventions II; (1992) https://doi.org/10.1117/12.137291
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Holmium laser angioplasty was performed in the atheromatous carotid artery of 10 rabbits to evaluate this mid-infrared laser as an alternative energy source for angioplasty. An additional 10 rabbits served as a control group. The laser emitted light at a wavelength of 2120 nm with pulse durations of 150 microsecond(s) . The energy density was 17.5 J/cm². Cross sections were analyzed in regard to laser specific injury 7 and 14 days following laser irradiation. Staining of (alpha) -actin was used to identify smooth muscle cells (SMC), and bromodesoxyuridine labeling was carried out to determine the extent of proliferating cells. Integrity of the lamina elastica interna fibers was disrupted in 6 of 10 animals. In all animals, loss of medial SMCs was observed 7 and 14 days after treatment. Quantification of SMCs undergoing DNA synthesis in the intima and media showed a significant increase of labelled cells following laser irradiation. This proliferative response resulted in a significant increase of intimal thickening after laser ablation.

Citation Download Citation

Karl Konstantin Haase M.D., Stefan Hassenstein M.D., Hartmut Hanke M.D., Sybille Hanke M.D., Martin Oberhoff M.D., and Karl R. Karsch M.D. "In-vivo holmium laser angioplasty", Proc. SPIE 1642, Diagnostic and Therapeutic Cardiovascular Interventions II, (28 August 1992); https://doi.org/10.1117/12.137291

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