Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

Benjamin Ehrenberg; Adina Lavi; Yeshayahu Nitzan; Zvi Malik; Hava Ladan; Fred M. Johnson; Jonathan L. Sessler

doi:10.1117/12.60947

1 June 1992 Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers

Benjamin Ehrenberg, Adina Lavi, Yeshayahu Nitzan, Zvi Malik, Hava Ladan, Fred M. Johnson, Jonathan L. Sessler

Proceedings Volume 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy; (1992) https://doi.org/10.1117/12.60947
Event: OE/LASE '92, 1992, Los Angeles, CA, United States

Abstract

Two types of photosensitizers are compared here for their singlet oxygen production and in vivo sensitizing capacity: Mg²⁺ and Zn²⁺-tetrabenzoporphyrin, which have a strong Q band at the HeNe laser line; and Cd-texaphyrin, with absorption at 770 nm. The singlet oxygen quantum yields in homogeneous solutions were determined by employing a singlet oxygen-destroyable fluorescent target. Photosensitizers of bacterial and human leukemic cells were carried out with these sensitizers, in comparison with HPD and Photofrin II. The new sensitizers were found to have high quantum yields for production of singlet oxygen in solutions. They also have comparable photosensitizing capacities of bacterial cells.

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Benjamin Ehrenberg, Adina Lavi, Yeshayahu Nitzan, Zvi Malik, Hava Ladan, Fred M. Johnson, and Jonathan L. Sessler "Spectroscopy, photokinetics, and cellular effect of far-red and near-infrared absorbing photosensitizers", Proc. SPIE 1645, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy, (1 June 1992); https://doi.org/10.1117/12.60947

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