Vibrational circular dichroism in molecules of pharmaceutical interest

Teresa B. Freedman; Denise M. Gigante; Mario J. Citra; M. Germana Paterlini

doi:10.1117/12.145258

1 May 1993 Vibrational circular dichroism in molecules of pharmaceutical interest

Teresa B. Freedman, Denise M. Gigante, Mario J. Citra, M. Germana Paterlini

Proceedings Volume 1890, Biomolecular Spectroscopy III; (1993) https://doi.org/10.1117/12.145258
Event: OE/LASE'93: Optics, Electro-Optics, and Laser Applications in Scienceand Engineering, 1993, Los Angeles, CA, United States

Abstract

Vibrational circular dichroism (VCD) spectra provide information on the solution conformations of chiral molecules. The CH-, OH-, NH-, and C equals O-stretching VCD features are particularly useful conformational probes. Molecules of pharmaceutical interest studied by VCD include biomimetic iron carriers, unsaturated peptides, the anticancer drug taxol and a series of type I antiarrhythmic drugs.

Citation Download Citation

Teresa B. Freedman, Denise M. Gigante, Mario J. Citra, and M. Germana Paterlini "Vibrational circular dichroism in molecules of pharmaceutical interest", Proc. SPIE 1890, Biomolecular Spectroscopy III, (1 May 1993); https://doi.org/10.1117/12.145258

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