New liposome-bound Ge(IV)-phthalocyanine (CGP 55398) for photodynamic therapy of tumors: preliminary studies

Anna Segalla; G. Re; Carla Milanesi; Giulio Jori; Hans-Georg Capraro; Klaus Schieweck; Ute Isele

doi:10.1117/12.168697

1 March 1994 New liposome-bound Ge(IV)-phthalocyanine (CGP 55398) for photodynamic therapy of tumors: preliminary studies

Anna Segalla, G. Re, Carla Milanesi, Giulio Jori, Hans-Georg Capraro, Klaus Schieweck, Ute Isele

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168697
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A phthalocyanine derivative with two cholesterol moieties as axial ligands to the central Ge(IV) ion efficiently photosensitizes the oxidative modification of L-tryptophan. Administration of liposome-bound GePc to Balb/c mice bearing a MS-2 fibrosarcoma yields a quantitative release of the dye to serum lipoproteins, followed by a selective accumulation in the tumor as well as a low content in the skin. At 24 h after injection of 0.76 mg/kg GePc, the tumor was irradiated with 600 - 700 nm light; tumor necrosis appeared in all treated mice as a consequence of extensive damage of cellular and stromal elements.

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Anna Segalla, G. Re, Carla Milanesi, Giulio Jori, Hans-Georg Capraro, Klaus Schieweck, and Ute Isele "New liposome-bound Ge(IV)-phthalocyanine (CGP 55398) for photodynamic therapy of tumors: preliminary studies", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168697

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