Preliminary clinical studies of PDT with meso-tetrahydroxyphenyl chlorin (m-THPC) as a photosensitizing agent for the treatment of early pharyngeal, esophageal, and bronchial carcinomas

Jean-Francois Savary; Philippe Monnier; Georges A. Wagnieres; Daniel Braichotte; Charlotte Fontolliet; Hubert van den Bergh

doi:10.1117/12.168671

1 March 1994 Preliminary clinical studies of PDT with meso-tetrahydroxyphenyl chlorin (m-THPC) as a photosensitizing agent for the treatment of early pharyngeal, esophageal, and bronchial carcinomas

Jean-Francois Savary, Philippe Monnier, Georges A. Wagnieres, Daniel Braichotte, Charlotte Fontolliet, Hubert van den Bergh

Author Affiliations +

Proceedings Volume 2078, Photodynamic Therapy of Cancer; (1994) https://doi.org/10.1117/12.168671
Event: Europto Biomedical Optics '93, 1993, Budapest, Hungary

Abstract

A new photosensitizer (PS), meso-tetrahydroxyphenyl-chlorin(m-THPC), has been clinically evaluated for photodynamic therapy (PDT) of early squamous cell carcinomas located in the upper aerodigestive tract, the oesophagus and the tracheobronchial tree. The injected doses ranged between 0.1 - 0.3 mg/kg m-THPC and the wavelength of the excitation light was either at 514 nm or 652 nm. The evaluation of the m-THPC induced phototoxicity was carried out on healthy mucosae of the bronchi, the oral cavity and the skin, using various `frontal' light distributors. Skin photosensitization tests were performed with a filtered Xenon white light source which simulates the solar emission spectrum at noon on a clear summer day at sea level at our latitude. At the present time, we are still searching for conditions where effective PDT with m-THPC of early carcinomas of the upper aerodigestive tract, the oesophagus and the tracheobronchial tree would show a real selectivity, i.e., destruction of the neoplastic tissue without necrosis of the surrounding normal tissue.

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Jean-Francois Savary, Philippe Monnier, Georges A. Wagnieres, Daniel Braichotte, Charlotte Fontolliet, and Hubert van den Bergh "Preliminary clinical studies of PDT with meso-tetrahydroxyphenyl chlorin (m-THPC) as a photosensitizing agent for the treatment of early pharyngeal, esophageal, and bronchial carcinomas", Proc. SPIE 2078, Photodynamic Therapy of Cancer, (1 March 1994); https://doi.org/10.1117/12.168671

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