In-vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

Ingrid Wang; Stefan Andersson-Engels; Ingrid Idvall; Christian Ingvar; Katarina Svanberg M.D.

doi:10.1117/12.176006

19 May 1994 In-vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin

Ingrid Wang, Stefan Andersson-Engels, Ingrid Idvall, Christian Ingvar, Katarina Svanberg M.D.

Proceedings Volume 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases; (1994) https://doi.org/10.1117/12.176006
Event: OE/LASE '94, 1994, Los Angeles, CA, United States

Abstract

A study in order to investigate the uptake of porphyrins in neoplasias in the female breast tissue and to evaluate the potential of fluorescence diagnostics for tumor demarcation was performed. Six women with positive mammography and cytological biopsies took part in the study. The patients were given Photofrin intravenously in a low dose of 0.35 mg/kg b.w. 24 hours before the planned surgical procedure. Immediately after surgery the pathological specimen were investigated with fluorescence spectroscopy following 405 nm laser excitation. Afterwards the investigated tissue sample was taken for histological preparation. The spectroscopic results were correlated with the histopathological diagnoses. The study shows a good demarcation between invasive or in situ cancerous tissue and the surrounding breast tissue, based on fluorescence data.

Citation Download Citation

Ingrid Wang, Stefan Andersson-Engels, Ingrid Idvall, Christian Ingvar, and Katarina Svanberg M.D. "In-vitro laser-induced fluorescence studies of breast tumors following low-dose injection of Photofrin", Proc. SPIE 2135, Advances in Laser and Light Spectroscopy to Diagnose Cancer and Other Diseases, (19 May 1994); https://doi.org/10.1117/12.176006

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