Advanced optics module for monitoring protein crystal growth in microgravity

Alan D. Kathman; Tammy C. Cole; Mark E. Wells; Greg Jenkins; Stan Koszelak; Alexander McPherson

doi:10.1117/12.177668

8 June 1994 Advanced optics module for monitoring protein crystal growth in microgravity

Alan D. Kathman, Tammy C. Cole, Mark E. Wells, Greg Jenkins, Stan Koszelak, Alexander McPherson

Proceedings Volume 2214, Space Instrumentation and Dual-Use Technologies; (1994) https://doi.org/10.1117/12.177668
Event: SPIE's International Symposium on Optical Engineering and Photonics in Aerospace Sensing, 1994, Orlando, FL, United States

Abstract

Understanding the phenomena of protein crystal growth has become a critical factor in the advancement of fundamental life sciences. To characterize this process, sensitive non-intrusive monitoring systems must be utilized in a micro-gravity environment. We believe detailed optical monitoring to be the superior technique for use in micro-gravity. The proposed approach includes monitoring the nucleation event, rate and form of crystal growth, and protein density variations throughout the cell volume with four different optical metrology methods running concurrently. The system will incorporate photon correlation spectroscopy, interferometry, Zernike phase contrast imagery, and high-resolution polarization microscopy. These four systems have all been combined into a single optical module that provides crystal growth process data. The module utilizes the emerging technologies of binary optics and solid optics to shrink and stabilize the system (patent-pending).

Citation Download Citation

Alan D. Kathman, Tammy C. Cole, Mark E. Wells, Greg Jenkins, Stan Koszelak, and Alexander McPherson "Advanced optics module for monitoring protein crystal growth in microgravity", Proc. SPIE 2214, Space Instrumentation and Dual-Use Technologies, (8 June 1994); https://doi.org/10.1117/12.177668

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