First clinical results with a new drug for PDT

Victor V. Sokolov; Valery I. Chissov; E. V. Filonenko; Raisa I. Yakubovskaya; Garry M. Sukhin; Maria G. Galpern; Georgy N. Vorozhtsov; Alexander V. Gulin; Margarita B. Zhitkova; Natalia N. Zharkova; Dmitrij N. Kozlov; V. V. Smirnov

doi:10.1117/12.199168

12 January 1995 First clinical results with a new drug for PDT

Victor V. Sokolov, Valery I. Chissov, E. V. Filonenko, Raisa I. Yakubovskaya, Garry M. Sukhin, Maria G. Galpern, Georgy N. Vorozhtsov, Alexander V. Gulin, Margarita B. Zhitkova, Natalia N. Zharkova, Dmitrij N. Kozlov, V. V. Smirnov

Author Affiliations +

Proceedings Volume 2325, Photodynamic Therapy of Cancer II; (1995) https://doi.org/10.1117/12.199168
Event: International Symposium on Biomedical Optics Europe '94, 1994, Lille, France

Abstract

After experimental investigation clinical trials of photodynamic therapy (PDT) with the new photosensitizer Photosens -- (AL-sulphonated phthalocyanine) -- have been started. Four patients (with basal cell carcinoma, sarcoma Kaposi and early stage lung cancer) were treated by PDT. After an intravenous injection of drug in dose 2.0 mg/kg b.w. tumors were exposed to frequency-doubled radiation of Nd:yttrium aluminate laser (670 nm) with power densities from 80 to 200 mW/sq cm and total energies up to 2144 J. Immunological and clinical observations of patients are performed. First results indicate the high efficacy of the new drug as a tumor photosensitizer.

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Victor V. Sokolov, Valery I. Chissov, E. V. Filonenko, Raisa I. Yakubovskaya, Garry M. Sukhin, Maria G. Galpern, Georgy N. Vorozhtsov, Alexander V. Gulin, Margarita B. Zhitkova, Natalia N. Zharkova, Dmitrij N. Kozlov, and V. V. Smirnov "First clinical results with a new drug for PDT", Proc. SPIE 2325, Photodynamic Therapy of Cancer II, (12 January 1995); https://doi.org/10.1117/12.199168

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