Optical properties of normal and malignant tissues in the nasopharynx and larynx

Calum E. MacAulay; Stephen Lam; Jianan Y. Qu; C. Man; M. Harries; Branko Palcic

doi:10.1117/12.209097

12 May 1995 Optical properties of normal and malignant tissues in the nasopharynx and larynx

Calum E. MacAulay, Stephen Lam, Jianan Y. Qu, C. Man, M. Harries, Branko Palcic

Proceedings Volume 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V; (1995) https://doi.org/10.1117/12.209097
Event: Photonics West '95, 1995, San Jose, CA, United States

Abstract

Differences in tissue autofluorescence between normal bronchial tissue and cancerous or pre cancerous bronchial tissue have been documented and exploited for the early detection of lung cancer (1,2) The larynx and nasopharynx have not been so well studied. Even with the most advanced fiber-optic equipment in experienced hands, the nasopharynx is an accessible but challenging area to examine. Small nasopharyngeal carcinoma are difficult to detect. For the larynx the challenge is the precise tumour localization which will allow more accurate staging of the malignant disease. The thought is that the tissue autofluorescence and tissue optical properties (absorption and scattering) which allow one to detect and localize early lesions in the bronchial tree may be similar in the larynx and nasopharynx and likewise exploitable for detection and delineation of lesions. The major characteristics of the autofluorescence properties of bronchial tissue, which may be found to be similar in other sites, are summarized below.

Citation Download Citation

Calum E. MacAulay, Stephen Lam, Jianan Y. Qu, C. Man, M. Harries, and Branko Palcic "Optical properties of normal and malignant tissues in the nasopharynx and larynx", Proc. SPIE 2395, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems V, (12 May 1995); https://doi.org/10.1117/12.209097

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