Laser ablation of normal porcine liver with the 805-nm diode laser and a diffuser fiber

Douglas M. Cromeens D.V.M.; Peggy T. Tinkey; L. Clifton Stephens; Kenneth N. Gray

doi:10.1117/12.240003

17 May 1996 Laser ablation of normal porcine liver with the 805-nm diode laser and a diffuser fiber

Douglas M. Cromeens D.V.M., Peggy T. Tinkey, L. Clifton Stephens, Kenneth N. Gray

Proceedings Volume 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI; (1996) https://doi.org/10.1117/12.240003
Event: Photonics West '96, 1996, San Jose, CA, United States

Abstract

The ability of the 1.06 Nd:YAG laser and the 805 nm diode laser to transurethrally and interstitially ablate prostate has been well documented by this lab and others. With the introduction of lower cost and physically smaller diode laser systems, and the potential for transcatheter and laparoscopic delivery of laser energy through diffuser fibers, laser ablation of tumors of the liver is feasible and could prove to be a cost effective treatment for this and other soft tissue applications. This study examined the acute pathologic effect of 805 nm diode laser radiation delivered via diffuser fibers on normal porcine liver. After preliminary dosimetry parameters were established in cadaveric canine liver, laparotomies were performed to expose the liver on domestic swine. Histopathological samples taken 3 hours after lasing revealed 4 distinct zones of tissue change. The outermost zone showed a 2 mm band of hemorrhage with disruption of hepatic cords adjacent to a zone of disruption of hepatic cords without hemorrhage. Working toward the fiber the next zone was intact with no visible changes. The innermost zone that was in contact with the fiber exhibited a very thin area of necrosis and char. The diameter of the outermost zone seemed to increase with increased wattage.

Citation Download Citation

Douglas M. Cromeens D.V.M., Peggy T. Tinkey, L. Clifton Stephens, and Kenneth N. Gray "Laser ablation of normal porcine liver with the 805-nm diode laser and a diffuser fiber", Proc. SPIE 2671, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VI, (17 May 1996); https://doi.org/10.1117/12.240003

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