CsI(Na)-based radiation detector for high-resolution imaging studies using iodine 125 in small-animal research

Andrew G. Weisenberger; Eric Bradley; Stan Majewski; Margaret Saha

doi:10.1117/12.277692

7 July 1997 CsI(Na)-based radiation detector for high-resolution imaging studies using iodine 125 in small-animal research

Andrew G. Weisenberger, Eric Bradley, Stan Majewski, Margaret Saha

Author Affiliations +

Proceedings Volume 3115, Hard X-Ray and Gamma-Ray Detector Physics, Optics, and Applications; (1997) https://doi.org/10.1117/12.277692
Event: Optical Science, Engineering and Instrumentation '97, 1997, San Diego, CA, United States

Abstract

We report on the development of a high resolution radiation imaging system which is capable of detecting and imaging the coincident gamma and x-ray emissions of the radioisotope iodine 125 (¹²⁵I). Iodine 125 is commonly available as a label to molecular biology probes. Iodine 125 decays via electron capture emitting a 35 keV gamma-ray with the prompt emission of several 27 - 32 keV x rays. A coincidence condition can be set to detect the ¹²⁵I decays thus reducing background radiation contribution to the image. We are testing the use of arrays of CsI(Na) crystal scintillators coupled to position sensitive photomultiplier tubes for this application. Laboratory studies have thus far been done on mice using a prototype of our detector which is intended to be used to image gene expression in live mice to advance research in neurobiology.

Citation Download Citation

Andrew G. Weisenberger, Eric Bradley, Stan Majewski, and Margaret Saha "CsI(Na)-based radiation detector for high-resolution imaging studies using iodine 125 in small-animal research", Proc. SPIE 3115, Hard X-Ray and Gamma-Ray Detector Physics, Optics, and Applications, (7 July 1997); https://doi.org/10.1117/12.277692

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available