Modulation of Photofrin II accumulation in C6 glioma cells by stimulation of beta-adrenergic receptors

Anna Cleta Croce; V. Mares; V. Lisa; D. Krajci; Giovanni F. Bottiroli

doi:10.1117/12.297827

29 December 1997 Modulation of Photofrin II accumulation in C6 glioma cells by stimulation of beta-adrenergic receptors

Anna Cleta Croce, V. Mares, V. Lisa, D. Krajci, Giovanni F. Bottiroli

Proceedings Volume 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III; (1997) https://doi.org/10.1117/12.297827
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The influence of drugs acting as (beta) -receptors agonists or antagonists on the uptake of Photofrin II in C6 glioma cultured cells was studied by microspectrofluorometric analysis. The pharmacological effect was evaluated on the semiconfluently grown cells, characterized by a long lasting uptake process and higher values of fluorescence intensity with respect to the solitary ones. Isoproterenol treatments resulted in a significant enhancement (by 50%) of the intracellular fluorescence signal of Photofrin II. This effect was hindered by contemporary treatments with equimolar alprenolol or propranolol, two (beta) -receptor antagonists, indicating a specific effect of isoproterenol. Both pharmacological activation of vesicular transport and changes in the membrane physical-chemico properties can explain the effects induced by drugs interacting with (beta) -receptor.

Citation Download Citation

Anna Cleta Croce, V. Mares, V. Lisa, D. Krajci, and Giovanni F. Bottiroli "Modulation of Photofrin II accumulation in C6 glioma cells by stimulation of beta-adrenergic receptors", Proc. SPIE 3191, Photochemotherapy: Photodynamic Therapy and Other Modalities III, (29 December 1997); https://doi.org/10.1117/12.297827

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