Infrared spectroscopy in biomedical diagnostics

Natalia I. Afanasyeva; Sergei F. Kolyakov; Vladilen S. Letokhov; Vjacheslav G. Artioushenko; Viktoriya N. Golovkina

doi:10.1117/12.297891

14 January 1998 Infrared spectroscopy in biomedical diagnostics

Natalia I. Afanasyeva, Sergei F. Kolyakov, Vladilen S. Letokhov, Vjacheslav G. Artioushenko, Viktoriya N. Golovkina

Proceedings Volume 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III; (1998) https://doi.org/10.1117/12.297891
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

Fiberoptic evanescent wave Fourier transform infrared (FEW- FTIR) spectroscopy using fiberoptic sensors operated in the attenuated total reflection (ATR) regime in the middle infrared (IR) region of the spectrum (850 - 1850 cm^-1) has recently found application in the diagnostics of tissues. The method is suitable for noninvasive and rapid (seconds) direct measurements of the spectra of normal and pathological tissues in vitro, ex vivo and in vivo. The aim of our studies is the express testing of various tumor tissues at the early stages of their development. The method is expected to be further developed for endoscopic and biopsy applications. We measured in vivo the skin normal and malignant tissues on surface (directly on patients) in various cases of basaloma, melanoma and nevus. The experiments were performed in the operating room for measurements of skin in the depth (under/in the layers of epidermis), human breast, stomach, lung, kidney tissues. The breast and skin tissues at different stages of tumor or cancer were distinguished very clearly in spectra of amide, side cyclic and noncyclic hydrogen bonded fragments of amino acid residuals, phosphate groups and sugars. Computer monitoring is being developed for diagnostics.

Citation Download Citation

Natalia I. Afanasyeva, Sergei F. Kolyakov, Vladilen S. Letokhov, Vjacheslav G. Artioushenko, and Viktoriya N. Golovkina "Infrared spectroscopy in biomedical diagnostics", Proc. SPIE 3195, Laser-Tissue Interaction, Tissue Optics, and Laser Welding III, (14 January 1998); https://doi.org/10.1117/12.297891

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KEYWORDS

Tissues

Skin

Tumors

Natural surfaces

Cancer

In vivo imaging

Melanoma

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