Optical magnetophoretic analysis of blood cells and microparticles

Svetlana B. Norina; Alexander N. Shalygin; Stanislav F. Rastopov

doi:10.1117/12.301129

1 January 1998 Optical magnetophoretic analysis of blood cells and microparticles

Svetlana B. Norina, Alexander N. Shalygin, Stanislav F. Rastopov

Proceedings Volume 3199, Biomedical Systems and Technologies II; (1998) https://doi.org/10.1117/12.301129
Event: BiOS Europe '97, 1997, San Remo, Italy

Abstract

The precise magnetophoretic measurements of magnetic susceptibility of red blood cells and sorbent microparticles fulfilled with the video-camera observation and light scattering detection were applied for the identification of the cellular free radical excess under oxidative stress, paramagnetic ions changes and the immunospecific binding detection. The fast and sensitive assay allows to determine weak paramagnetic or diamagnetic shifts relatively surrounding solution connected with hematological and metabolic cellular disorders, external chemical influences by ions and organic molecules additions in range 10^-4 - 10^-6 M. The autoregistration of magnetophoresis facilitated the analysis of the functional states of cells and the macromolecular binding detection.

Citation Download Citation

Svetlana B. Norina, Alexander N. Shalygin, and Stanislav F. Rastopov "Optical magnetophoretic analysis of blood cells and microparticles", Proc. SPIE 3199, Biomedical Systems and Technologies II, (1 January 1998); https://doi.org/10.1117/12.301129

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