Direct effects of laser irradiation on cells in photodynamic therapy

T. Cheng-Yi Liu; Junheng Li M.D.; Chao-Ying Zen

doi:10.1117/12.330174

2 November 1998 Direct effects of laser irradiation on cells in photodynamic therapy

T. Cheng-Yi Liu, Junheng Li M.D., Chao-Ying Zen

Proceedings Volume 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery; (1998) https://doi.org/10.1117/12.330174
Event: 1997 Shanghai International Conference on Laser Medicine and Surgery, 1997, Shanghai, China

Abstract

Liu TCY et a! (SPIE 2887, pp. 140-15 1, 1996) have put forward the biological information model on low intensity laser irradiation (BIML). Low intensity laser irradiation couples with intracellular messenger through the chromophore absorption in the cell membrane: hot-color (red, orange, yellow) laser irradiation activates cAMP phosphodiesterase through G, protein or activates phosphoinositide phospholipase C (PLC) through Gq protein, or activates one of receptor-associated kinases: cAMPL; cold-color (green, blue, violet) laser irradiation activates adenylate cyclase through G, protein: cAMP'l'. In this paper, we applied BIML to studying the direct effects of laser irradiation on cells in photodynamic therapy. It was concluded that cold color laser irradiation PDT is better than hot color laser irradiation PDT from the viewpoint of the effects on cells and the short term effects on cancer, but hot color laser irradiation PDT is superior to cold color laser irradiation PDT with respect to the long term effects on cancer. Key Words: photodynamic therapy; cancer; transmemberane signal transduction

Citation Download Citation

T. Cheng-Yi Liu, Junheng Li M.D., and Chao-Ying Zen "Direct effects of laser irradiation on cells in photodynamic therapy", Proc. SPIE 3344, 1997 Shanghai International Conference on Laser Medicine and Surgery, (2 November 1998); https://doi.org/10.1117/12.330174

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