Low-coherence tomography technique in biological tissues

Ge Kou; Wanrong Gao; ChunKan Tao; Luguo Hao

doi:10.1117/12.317852

7 August 1998 Low-coherence tomography technique in biological tissues

Ge Kou, Wanrong Gao, ChunKan Tao, Luguo Hao

Proceedings Volume 3548, Biomedical Optics and Lasers: Diagnostics and Treatment; (1998) https://doi.org/10.1117/12.317852
Event: Photonics China '98, 1998, Beijing, China

Abstract

Low coherence optical tomography (OCT) is a novel technique with high resolution for rapid, noninvasive imaging in living biological tissues. With this technique, a thin 'optical section' within a thick biological specimen can be obtained. Using a combination of the principles of low-coherence interferometry and confocal microscopy, OCT can provide micron-scale tomographic imaging of internal tissue microstructures. In OCT, enhanced optical sectioning performance in biological tissues (highly scattering media) is achieved through high detection sensitivity and high contrast rejection of out-of-focus light. In this paper, basic principle and recent advances in optical coherence tomography are described. The emphasis is to analyze some key problems in OCT setup. Light attenuation and scanning system are studied in detail. A theoretical model for low-coherence optical tomography in highly scattering media (biological tissues) is given. The authors will show that OCT images may be significantly affected by multiple scattering associated with the refractive index inhomogeneities found in scattering media such as biological tissues. At last, a conclusion suggests that OCT is a very promising technique for clinical application because of its simple theory and low cost.

Citation Download Citation

Ge Kou, Wanrong Gao, ChunKan Tao, and Luguo Hao "Low-coherence tomography technique in biological tissues", Proc. SPIE 3548, Biomedical Optics and Lasers: Diagnostics and Treatment, (7 August 1998); https://doi.org/10.1117/12.317852

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KEYWORDS

Optical coherence tomography

Tissues

Tissue optics

Confocal microscopy

Scattering media

Tomography

Light sources

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