Quantitative optical parameter determination in tissues using diffuse photon-density waves: the impact of measurement geometry and source modulation frequency

Thorsten Spott; Tuan H. Pham; Lars Othar Svaasand; Joshua B. Fishkin; Bruce J. Tromberg

doi:10.1117/12.356837

15 July 1999 Quantitative optical parameter determination in tissues using diffuse photon-density waves: the impact of measurement geometry and source modulation frequency

Thorsten Spott, Tuan H. Pham, Lars Othar Svaasand, Joshua B. Fishkin, Bruce J. Tromberg

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Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356837
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

The measurement of the propagation characteristics of Diffuse Photon-Density Waves (DPDW) is a viable path to determine the optical properties of tissue, i.e. the absorption and the reduced scattering coefficient. The technique allows to take measurements from bulk tissue, either by interstitial placement (infinite medium measurement) or superficial placement (semi-infinite medium measurement) of the source and detection fibers. Treatment of the tissue prior to measurement is unnecessary, such that changes to the structure of the tissue, and thus the optical properties, can be avoided. The optical properties can then be recovered by application of a diffusion model. When using a semi-infinite medium model, non-invasive in vivo measurements are feasible. While the theory is well established and verified by phantom measurements, the small amount of published data for biological tissue acquired by DPDW measurements suggests that there are still open practical problems, both concerning the measurement technique and the application of the diffusion model. In this study, we investigate the optimal choice of modulation frequencies for extracting a maximum amount of information on the scattering and absorption properties, examine different measurement setups, analyze how amplitude and phase data should be combined and compare the quality of infinite and semi-infinite medium measurements. The considerations are supported by experimental data, based on measurements from chicken and turkey breast muscle with modulation frequencies of up to 0.4 GHz.

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Thorsten Spott, Tuan H. Pham, Lars Othar Svaasand, Joshua B. Fishkin, and Bruce J. Tromberg "Quantitative optical parameter determination in tissues using diffuse photon-density waves: the impact of measurement geometry and source modulation frequency", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356837

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