Realistic dynamic brain phantom and time-resolved measurement

Daigo Imai; Kenji Tanaka; Yukari Tanikawa; Yoshio Tsunazawa; Hiroshi Kawamura; Yukio Yamada

doi:10.1117/12.356800

15 July 1999 Realistic dynamic brain phantom and time-resolved measurement

Daigo Imai, Kenji Tanaka, Yukari Tanikawa, Yoshio Tsunazawa, Hiroshi Kawamura, Yukio Yamada

Proceedings Volume 3597, Optical Tomography and Spectroscopy of Tissue III; (1999) https://doi.org/10.1117/12.356800
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

In the process of developing optical tomographic imaging systems for diagnosis of disease and study of brain functions of human heads, we need realistic optical phantoms which anatomically and optically simulate human heads with complicated and multi-layered structures. Previously we have reported design and fabrication methods of optical head phantoms based on MRI images of a human head. The phantoms were simulated the multilayered structure with different optical properties at five layers; i.e., skin, skull, cerebrospinal fluid layer, gray matter and white matter. Also the phantoms which were mainly made of solid resin had dynamic parts to simulate the temporal variation of physiological functions in brain. The optical properties of the liquid circulating through the dynamic part can be changed to simulate the change in oxygenation states. The material of the skin layer has been changed from solid resin to soft rubber in order to have a good contact with optical fibers. The fabricated optical head phantom has been used in time-resolved spectroscopic measurement, and the usefulness of the dynamic optical head phantom is verified.

Citation Download Citation

Daigo Imai, Kenji Tanaka, Yukari Tanikawa, Yoshio Tsunazawa, Hiroshi Kawamura, and Yukio Yamada "Realistic dynamic brain phantom and time-resolved measurement", Proc. SPIE 3597, Optical Tomography and Spectroscopy of Tissue III, (15 July 1999); https://doi.org/10.1117/12.356800

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