Imaging of absorption coefficients and lifetimes in the scattering medium with heterogeneous fluorophore distribution using simply bound constrained minimization

Ranadhir Roy; Eva Marie Sevick-Muraca

doi:10.1117/12.351038

2 July 1999 Imaging of absorption coefficients and lifetimes in the scattering medium with heterogeneous fluorophore distribution using simply bound constrained minimization

Ranadhir Roy, Eva Marie Sevick-Muraca

Author Affiliations +

Proceedings Volume 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation; (1999) https://doi.org/10.1117/12.351038
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

In this contribution, the inverse optical imaging problem is formulated as both simply bound-constrained and unconstrained minimization problems in order to illustrate the reduction in computational time and storage. The Galerkin finite element method is used for the numerical solution of the excitation and emission diffusion equations. The inverse approach employs the truncated Newton method with trust region, and modified automatic reverse differentiation method is used to calculate the gradients thus sped up the computation of the optimization problem.

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Ranadhir Roy and Eva Marie Sevick-Muraca "Imaging of absorption coefficients and lifetimes in the scattering medium with heterogeneous fluorophore distribution using simply bound constrained minimization", Proc. SPIE 3600, Biomedical Imaging: Reporters, Dyes, and Instrumentation, (2 July 1999); https://doi.org/10.1117/12.351038

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