Light dosimetry technique for endoscopic PDT using microlens optical fiber

Steven L. Jacques

doi:10.1117/12.350033

14 June 1999 Light dosimetry technique for endoscopic PDT using microlens optical fiber

Steven L. Jacques

Proceedings Volume 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical; (1999) https://doi.org/10.1117/12.350033
Event: BiOS '99 International Biomedical Optics Symposium, 1999, San Jose, CA, United States

Abstract

A simple procedure is presented for determining the irradiance of light striking tissues during light delivery using a microlens optical fiber via an endoscope. The particular example is photodynamic therapy (PDT) of laryngeal cancer. A microlens optical fiber is an optical fiber with a small lens assembly at its terminus which magnifies the image of the end of the fiber yielding a uniform irradiance in a plane distant from the fiber. Prior to the therapy, the relation between fiber-target distance, h [cm], and the diameter of the uniform beam, d(h) [cm], was established and the area of the beam was calculated: A(h) equals (pi) d(h)²/4. The laser power P [W] required to achieve a desired irradiance E [W/cm²] was P(h) equals EA(h), and this relation was prepared as a simple graph for routine use in the clinic. During the therapy, the doctor advances the optical fiber through the working channel of the endoscope to touch the target tissue site while observing through the optical channel, and marks the fiber on the outside of the endoscope. The doctor then retracts the fiber until an aiming beam transmitted through the fiber fully illuminates the desired target area, and again marks the fiber on the outside of the endoscope. The difference in the two marks on the fiber outside the endoscope yields h, the height of the fiber above the target tissue. The laser operator then uses the P(h) equals EA(h) graph to select the proper laser power to achieve the desired E. Although trivially simple, this dosimetry procedure was critical to the proper implementation of PDT for laryngeal cancer.

Citation Download Citation

Steven L. Jacques "Light dosimetry technique for endoscopic PDT using microlens optical fiber", Proc. SPIE 3601, Laser-Tissue Interaction X: Photochemical, Photothermal, and Photomechanical, (14 June 1999); https://doi.org/10.1117/12.350033

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available