Ultrasound-assisted optical measurement for observation inside a scattering medium

Masaki Hisaka; Tadao Sugiura; Satoshi Kawata

doi:10.1117/12.347786

7 May 1999 Ultrasound-assisted optical measurement for observation inside a scattering medium

Masaki Hisaka, Tadao Sugiura, Satoshi Kawata

Proceedings Volume 3740, Optical Engineering for Sensing and Nanotechnology (ICOSN '99); (1999) https://doi.org/10.1117/12.347786
Event: Optical Engineering for Sensing and Nanotechnology (ICOSN '99), 1999, Yokohama, Japan

Abstract

We have developed an optical measurement method to investigate the inside of scattering media by using focused ultrasound to specify the measuring point. This method enables us to observe the internal structure of human tissue non-invasively for biomedical applications. This method may give us various kinds of material information such as spectroscopic characteristics. To get the information from only particular region in a tissue sample with light, we use a focused ultrasound. At the focal region of the ultrasound, refractive index of the tissue changes with strong acoustic field. So a part of incident light reflects at the focal region of the ultrasound. The reflected light has information of the sample. According to the scanning of the sample, we can get an image of the sample. In our experiments, we have observed samples that consist of an agarose block which contains a piece of agarose cube stained with dye as absorbing material. The intensity of reflected light from the focal region of the ultrasound decreased when the measuring point was in the stained agarose section, because incident light was absorbed with the dye. Furthermore, we have observed a sample with a weak scattering object made of agarose in strong scattering agarose that contains PMMA particles.

Citation Download Citation

Masaki Hisaka, Tadao Sugiura, and Satoshi Kawata "Ultrasound-assisted optical measurement for observation inside a scattering medium", Proc. SPIE 3740, Optical Engineering for Sensing and Nanotechnology (ICOSN '99), (7 May 1999); https://doi.org/10.1117/12.347786

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