Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI

Henkjan J. Huisman; J. O. Barentsz

doi:10.1117/12.383415

20 April 2000 Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI

Henkjan J. Huisman, J. O. Barentsz

Proceedings Volume 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images; (2000) https://doi.org/10.1117/12.383415
Event: Medical Imaging 2000, 2000, San Diego, CA, United States

Abstract

Contrast enhanced MRI (CE-MRI) is increasingly being used for tumor characterization as well as therapy response monitoring. We are investigating the diagnostic value of fast, multi-slice [1.5X1.5X5(mm)] CE-MRI with a time interval of 2(s) to enables estimating perfusion parameters. A clinical visualization tool is being developed that estimates curve parameters on a per voxel basis to be able to analyze the heterogeneous tumor physiology. MRI image noise strongly affects the (perfusion) related start-of-enhancement and time- to-peak estimates especially in low contrast curves. We therefore developed a robust estimation method. It was tested on realistic simulations and in vivo CE-MRI data and compared to existing methods. The new method is shown to be more accurate, precise and robust than common least-squares optimization based methods.

Citation Download Citation

Henkjan J. Huisman and J. O. Barentsz "Accurate estimation of contrast agent dynamics in fast contrast-enhanced MRI", Proc. SPIE 3978, Medical Imaging 2000: Physiology and Function from Multidimensional Images, (20 April 2000); https://doi.org/10.1117/12.383415

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