Application of IR and NIR fiber optic imaging in thermographic and spectroscopic diagnosis of atherosclerotic vulnerable plaques: preliminary experience

Morteza Naghavi; Tania Khan; Bujin Gu; Babs R. Soller; Peter Melling; Mohammed Asif; Khawar Gul; Mohammad Madjid; S. Ward Casscells; James T. Willerson

doi:10.1117/12.409909

15 December 2000 Application of IR and NIR fiber optic imaging in thermographic and spectroscopic diagnosis of atherosclerotic vulnerable plaques: preliminary experience

Morteza Naghavi, Tania Khan, Bujin Gu, Babs R. Soller, Peter Melling, Mohammed Asif, Khawar Gul, Mohammad Madjid, S. Ward Casscells, James T. Willerson

Author Affiliations +

Proceedings Volume 4130, Infrared Technology and Applications XXVI; (2000) https://doi.org/10.1117/12.409909
Event: International Symposium on Optical Science and Technology, 2000, San Diego, CA, United States

Abstract

Despite major advances in cardiovascular science and technology during the past three decades, approximately half of all myocardial infarctions and sudden deaths occur unexpectedly. It is widely accepted that coronary atherosclerotic plaques and thrombotic complications resulting from their rupture or erosion are the underlying causes of this major health problem. The majority of these vulnerable plaques exhibit active inflammation, a large necrotic lipid core, a thin fibrous cap, and confer a stenosis of less than 70%. These lesions are not detectable by stress testing or coronary angiography. Our group is exploring the possibility of a functional classification based on physiological variables such as plaque temperature, pH, oxygen consumption, lactate production etc. We have shown that heat accurately locates the inflamed plaques. We also demonstrated human atherosclerotic plaques are heterogeneous with regard to pH and hot plaques and are more likely to be acidic. To develop a nonsurgical method for locating the inflamed plaques, we are developing both IR fiber optic imaging and NIR spectroscopic systems in our laboratory to detect hot and acidic plaque in atherosclerotic arterial walls. Our findings introduce the possibility of an isolated/combined IR and NIR fiber optic catheter that can bring new insight into functional assessment of atherosclerotic plaque and thereby detection of active and inflamed lesions responsible for heart attacks and strokes.

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Morteza Naghavi, Tania Khan, Bujin Gu, Babs R. Soller, Peter Melling, Mohammed Asif, Khawar Gul, Mohammad Madjid, S. Ward Casscells, and James T. Willerson "Application of IR and NIR fiber optic imaging in thermographic and spectroscopic diagnosis of atherosclerotic vulnerable plaques: preliminary experience", Proc. SPIE 4130, Infrared Technology and Applications XXVI, (15 December 2000); https://doi.org/10.1117/12.409909

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