Noninvasive laser Raman detection of carotenoid antioxidants in living human skin

Werner Gellermann; Igor V. Ermakov; Maia R. Ermakova; Robert W. McClane

doi:10.1117/12.427803

21 May 2001 Noninvasive laser Raman detection of carotenoid antioxidants in living human skin

Werner Gellermann, Igor V. Ermakov, Maia R. Ermakova, Robert W. McClane

Proceedings Volume 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI; (2001) https://doi.org/10.1117/12.427803
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

We have used resonance Raman scattering as a novel non- invasive optical technology to measure carotenoid antioxidants in human skin of healthy volunteers. Using blue-green laser excitation, clearly distinguishable carotenoid Raman spectra are obtained which are superimposed on a large skin autofluorescence background. The Raman spectra are obtained rapidly, i.e. within about 30 seconds, and the required laser light exposure levels are well within safety standards. Our technique can be used for rapid screening of carotenoid antioxidant levels in large populations and may have applications for assessing the risk for cutaneous diseases.

Citation Download Citation

Werner Gellermann, Igor V. Ermakov, Maia R. Ermakova, and Robert W. McClane "Noninvasive laser Raman detection of carotenoid antioxidants in living human skin", Proc. SPIE 4244, Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems XI, (21 May 2001); https://doi.org/10.1117/12.427803

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