Study of the characteristics of protease-activated NIR fluorescent probes in tumors by using a 3D high-resolution image system

Yueqing Gu; Britton Chance; Ching Hsuan Tung; Ralph Weissleder

doi:10.1117/12.434538

29 June 2001 Study of the characteristics of protease-activated NIR fluorescent probes in tumors by using a 3D high-resolution image system

Yueqing Gu, Britton Chance, Ching Hsuan Tung, Ralph Weissleder

Author Affiliations +

Proceedings Volume 4250, Optical Tomography and Spectroscopy of Tissue IV; (2001) https://doi.org/10.1117/12.434538
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The objective of this paper is to study the distribution of the near infrared contrast agents delivered to mice bearing with small tumors in subsurface. Two kinds of contrast agents, NN382:ex760nm/em800nm and CY5.5:ex660nm/em700nm, which were activated by specific enzymes in tumors after bounded with certain delivery vehicle, were studied by using the 3D high spatial resolution image system. Flavoprotein and Nicotinamide adenine dinucleotide in tissue are measured simultaneously as intrinsic agents for study the effect of extrinsic contrast agents on redox state in tumor.

Citation Download Citation

Yueqing Gu, Britton Chance, Ching Hsuan Tung, and Ralph Weissleder "Study of the characteristics of protease-activated NIR fluorescent probes in tumors by using a 3D high-resolution image system", Proc. SPIE 4250, Optical Tomography and Spectroscopy of Tissue IV, (29 June 2001); https://doi.org/10.1117/12.434538

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