Development of an endoscopic fluorescence image-guided OCT probe for oral cancer detection

Roger J. McNichols; Ashok Gowda; Brent A. Bell; Richard M. Johnigan; Karen H. Calhoun; Massoud Motamedi

doi:10.1117/12.427941

4 June 2001 Development of an endoscopic fluorescence image-guided OCT probe for oral cancer detection

Roger J. McNichols, Ashok Gowda, Brent A. Bell, Richard M. Johnigan, Karen H. Calhoun, Massoud Motamedi

Proceedings Volume 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III; (2001) https://doi.org/10.1117/12.427941
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Oral squamous cell carcinoma is a disease which progresses through a number of well-defined morphological and biochemical changes. Optical coherence tomography (OCT) is a rapidly-evolving, non-invasive imaging modality which allows detailed probing of subsurface tissue structures with resolution on the order of microns. While this technique offers tremendous potential as a diagnostic tool for detection and characterization of oral cancer, OCT imaging is presently associated with a field of view on the order of millimeters, and acquisition time on the order of seconds. Thus, OCT's utility as a rapid cancer screening technique is presently limited. On the other hand, imaging of tissue autofluorescence provides a very rapid, high-throughput method for cancer screening. However, while autofluorescence measures may be sensitive to cancer, they are often non- specific and lead to a large number of false positives. In the present work, we have developed a fluorescence image guided optical coherence tomographic (FIG-OCT) probe in which tissue autofluorescence images are simultaneously used to guide OCT image acquisition of suspicious regions in real time. We have begun pre-clinical pilot studies with this instrument in a DMBA-induced model of oral cancer in the hamster cheek pouch. Initial results indicate that the FIG- OCT approach shows promise as a rapid and effective tool for screening of oral cancer.

Citation Download Citation

Roger J. McNichols, Ashok Gowda, Brent A. Bell, Richard M. Johnigan, Karen H. Calhoun, and Massoud Motamedi "Development of an endoscopic fluorescence image-guided OCT probe for oral cancer detection", Proc. SPIE 4254, Biomedical Diagnostic, Guidance, and Surgical-Assist Systems III, (4 June 2001); https://doi.org/10.1117/12.427941

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