Cavitation-induced drug delivery in tumors for cancer chemotherapy: animal studies

Rinat O. Esenaliev; Irina V. Larina; Yuliana Ivanova; Taras V. Ashitkov; Robert Thomas; B. Mark Evers

doi:10.1117/12.434726

9 July 2001 Cavitation-induced drug delivery in tumors for cancer chemotherapy: animal studies

Rinat O. Esenaliev, Irina V. Larina, Yuliana Ivanova, Taras V. Ashitkov, Robert Thomas, B. Mark Evers

Proceedings Volume 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical; (2001) https://doi.org/10.1117/12.434726
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

Recently we proposed to use laser- and ultrasound-induced cavitation to enhance delivery of anti-cancer agents from blood into tumor cells through tumor capillary wall, interstitium, and cancer cell membrane. Cavitation threshold can be lowered by using microparticles (with certain optical and acoustic properties) which can accumulate in tumors after injection in blood. Lower cavitation threshold allows for local and pronounced cavitation in tumors and, therefore, may provide safe and efficient delivery of anti-cancer drugs in cancer cells without damage to normal tissues by laser or ultrasound radiation. In this paper, we studied enhanced penetration of model macromolecular (rhodamine-dextran) and real anti- cancer (5-FU) drugs and efficacy of cancer therapy with the use of this technique in nude mice bearing human colon tumors KM20. Our studies showed enhanced penetration of the drugs in irradiated tumors and significant improvement of cancer therapy when radiation was applied in combination with polystyrene particle and 5-FU injections. Complete tumor regression of irradiated tumors was obtained when optimum conditions were used. Our results suggest that this technique can potentially be used for efficient and safe cancer chemotherapy.

Citation Download Citation

Rinat O. Esenaliev, Irina V. Larina, Yuliana Ivanova, Taras V. Ashitkov, Robert Thomas, and B. Mark Evers "Cavitation-induced drug delivery in tumors for cancer chemotherapy: animal studies", Proc. SPIE 4257, Laser-Tissue Interaction XII: Photochemical, Photothermal, and Photomechanical, (9 July 2001); https://doi.org/10.1117/12.434726

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