Dynamic behavior of photosensitizers after multiphoton excitation

David T. Cramb; Rebecca L. Goyan

doi:10.1117/12.424585

24 April 2001 Dynamic behavior of photosensitizers after multiphoton excitation

David T. Cramb, Rebecca L. Goyan

Proceedings Volume 4262, Multiphoton Microscopy in the Biomedical Sciences; (2001) https://doi.org/10.1117/12.424585
Event: BiOS 2001 The International Symposium on Biomedical Optics, 2001, San Jose, CA, United States

Abstract

The spectroscopy and photochemistry of protoporphyrin IX (PpIX) in ethanol and in Triton X-100 micelle solution and Verteporfin in methanol and Triton X-100 micelle solution have been examined using nea infrared two-photon excitation (TPE). TPE will allow photodynamic therapy with highly localized light dosage. For PpIX, we have determined that the photochemistry subsequent to TPE is very similar to that found for one-photon excitation. Moreover, the photoproducts observed possess very intense two-photon excitation fluorescence spectra, which allows their detection at low relative concentrations. Verteporfin displays photodynamic behavior in methanol similar to that of PpIX in ethanol. However, in micelle solution Verteporfin exhibits photodynamic behavior indicative of two sensitizer populations, excimers and monomers. Photochemical models are presented.

Citation Download Citation

David T. Cramb and Rebecca L. Goyan "Dynamic behavior of photosensitizers after multiphoton excitation", Proc. SPIE 4262, Multiphoton Microscopy in the Biomedical Sciences, (24 April 2001); https://doi.org/10.1117/12.424585

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