Spectral characteristic analysis of lung cancer serum

Xiao Zhou Li; Huiqiang Jin; Huasheng Liu; Jianhua Ding; Junxiu Lin

doi:10.1117/12.447146

31 October 2001 Spectral characteristic analysis of lung cancer serum

Xiao Zhou Li, Huiqiang Jin, Huasheng Liu, Jianhua Ding, Junxiu Lin

Proceedings Volume 4432, Diagnostic Optical Spectroscopy in Biomedicine; (2001) https://doi.org/10.1117/12.447146
Event: European Conferences on Biomedical Optics, 2001, Munich, Germany

Abstract

Spectral changes of lung cancer serum in the process of tumor evolution were investigated in this study. We kept close watch on the tumor progression of a group of patients, and measured their serum spectra using 488.0nm and 514.5nm excitation of an Ar-ion laser once a week. There was no apparent change observed in fluorescence spectrum in different period. However, the relative intensity of three Raman peaks (mode A, B and C) decreased every week later. For quantitative analysis of such changes, a parameter I_r (relative intensity of C Raman peak) was introduced and Ir-value was calculated. Calculation showed that I_r-value was degressive with tumor evolution, but (beta) (I_r5145 /I_r4880) varied irregularly. To the end, no Raman peak was observed. We assumed that three Raman peaks were derived from beta carotene. It indicated that the content of beta carotene decreased with the aggravation of lung cancer.

Citation Download Citation

Xiao Zhou Li, Huiqiang Jin, Huasheng Liu, Jianhua Ding, and Junxiu Lin "Spectral characteristic analysis of lung cancer serum", Proc. SPIE 4432, Diagnostic Optical Spectroscopy in Biomedicine, (31 October 2001); https://doi.org/10.1117/12.447146

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