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On the capillary level of intact organs of humans and mammals, fields of gradients of all measurable parameters are found exclusively. Therefore, a precise monitoring e.g. of hemoglobin concentration (Hb) and oxygenation (HbO2) in the microcosm of blood capillaries is only possible when the heterogeneity of tissue data is recorded at a representative number of measuring points. For the collecting of the required data both stochastic or imaging techniques can be applied.
Manfred D. Kessler,Paul Dan Cristea,Rainer Knaelmann, andPhilipp Wittwer
"2D imaging of intracapillary Hb-concentration and oxygenation in the skin of the human forehead in different ages", Proc. SPIE 4623, Functional Monitoring and Drug-Tissue Interaction, (5 June 2002); https://doi.org/10.1117/12.469446
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Manfred D. Kessler, Paul Dan Cristea, Rainer Knaelmann, Philipp Wittwer, "2D imaging of intracapillary Hb-concentration and oxygenation in the skin of the human forehead in different ages," Proc. SPIE 4623, Functional Monitoring and Drug-Tissue Interaction, (5 June 2002); https://doi.org/10.1117/12.469446