Morphology, properties, and dynamics of live cell in-vitro biomolecular interactions at surfaces and interfaces: analysis by scanning probe microscopy

Sverre Myhra

doi:10.1117/12.469735

14 November 2002 Morphology, properties, and dynamics of live cells in vitro, biomolecular interactions at surfaces and interfaces- analysis by scanning probe microscopy

Sverre Myhra

Author Affiliations +

Proceedings Volume 4937, Biomedical Applications of Micro- and Nanoengineering; (2002) https://doi.org/10.1117/12.469735
Event: SPIE's International Symposium on Smart Materials, Nano-, and Micro- Smart Systems, 2002, Melbourne, Australia

Abstract

The scanning probe microscope (SPM) system is emerging as an increasingly important tool for non-intrusive interrogation of live cells in vitro. Its particular merit is that it retains complete functionality in a biocompatible fluid environment and can track the dynamics of cellular processes in real time and real space at nm resolution, as an imaging tool, and with pN force-sensing/imposing resolution, as an interaction tool. However, a live cell is a fragile object; meeting the requirements of non-intrusiveness presents a challenging task. The better-known recent contributions of SPM towards explanatory and predictive descriptions of biomolecular interactions at surfaces and interfaces will also be reviewed, and some recent attempts to reconfigure the SPM platform for demonstration of novel bio-device applications will be described.

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Sverre Myhra "Morphology, properties, and dynamics of live cells in vitro, biomolecular interactions at surfaces and interfaces- analysis by scanning probe microscopy", Proc. SPIE 4937, Biomedical Applications of Micro- and Nanoengineering, (14 November 2002); https://doi.org/10.1117/12.469735

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KEYWORDS

Atomic force microscopy

Scanning probe microscopy

In vitro testing

Biological research

Adsorption

Interfaces

Magnetism

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