Laser-induced macular holes demonstrate impaired choroidal perfusion

Jeremiah Brown Jr.; Ronald D. Allen; Harry Zwick; Steven T. Schuschereba; David J. Lund; Bruce E. Stuck

doi:10.1117/12.488644

20 June 2003 Laser-induced macular holes demonstrate impaired choroidal perfusion

Jeremiah Brown Jr., Ronald D. Allen, Harry Zwick, Steven T. Schuschereba, David J. Lund, Bruce E. Stuck

Proceedings Volume 4953, Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III; (2003) https://doi.org/10.1117/12.488644
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Choroidal perfusion was evaluated following the creation of a laser induced macular hole in a nonhuman primate model. Two Rhesus monkeys underwent macular exposures delivered by a Q-switched Nd:YAG laser. The lesions were evaluated with fluorescein angiography and indocyanine green (ICG) angiography . Each lesion produced vitreous hemorrhage and progressed to a full thickness macular hole. ICG angiography revealed no perfusion of the choriocapillaris beneath the lesion centers. Histopathologic evaluation showed replacement of the choriocapillaris with fibroblasts and connective tissue. Nd:YAG, laser-induced macular holes result in long term impairment of choroidal perfusion at the base of the hole due to choroidal scarring and obliteration of the choriocapillaris.

Citation Download Citation

Jeremiah Brown Jr., Ronald D. Allen, Harry Zwick, Steven T. Schuschereba, David J. Lund, and Bruce E. Stuck "Laser-induced macular holes demonstrate impaired choroidal perfusion", Proc. SPIE 4953, Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III, (20 June 2003); https://doi.org/10.1117/12.488644

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