Confocal microendoscopy with chromatic sectioning

Pierre Mark Lane; Robert P. Elliott; Calum E. MacAulay

doi:10.1117/12.485552

2 July 2003 Confocal microendoscopy with chromatic sectioning

Pierre Mark Lane, Robert P. Elliott, Calum E. MacAulay

Proceedings Volume 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II; (2003) https://doi.org/10.1117/12.485552
Event: Biomedical Optics, 2003, San Jose, CA, United States

Abstract

Placing a spatial light modulator, such as the Texas Instruments Digital Micromirror Device (DMD), in the light path of a microscope enables a variety of novel applications. One application enables reflectance in vivo confocal imaging of cells and tissue structure through a fiber-optic image guide. While multi-wavelength reflectance confocal microendoscopy with optical sectioning is a requirement for a clinically useful device, some form of axial scanning is also necessary. This is readily achieved using a multi-element lens system with some form of mechanical translation, however, this generally results in large probes and high cost. These limitations can be overcome using a two-element GRIN lens system in which the traditionally undesirable chromatic aberration of such a system can be exploited to allow for color-encoded optical sectioning. In our system a wavelength encoding range of 200 nm permits a sectioning range of 40 μm from the tip of the probe into the tissue.

Citation Download Citation

Pierre Mark Lane, Robert P. Elliott, and Calum E. MacAulay "Confocal microendoscopy with chromatic sectioning", Proc. SPIE 4959, Spectral Imaging: Instrumentation, Applications, and Analysis II, (2 July 2003); https://doi.org/10.1117/12.485552

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