Photodynamic therapy and fluorescent diagnostics of skin cancer with radochlorine and photosense: comparing efficacy and toxicity

Elena G. Vakulovskaya M.D.; Yuriy V. Kemov; Igor D. Zalevsky; Andrew V. Reshetnikov; Loubov V. Umnova; Georgiu N. Vorozhcsov

doi:10.1117/12.537787

14 June 2004 Photodynamic therapy and fluorescent diagnostics of skin cancer with radochlorine and photosense: comparing efficacy and toxicity

Elena G. Vakulovskaya M.D., Yuriy V. Kemov, Igor D. Zalevsky, Andrew V. Reshetnikov, Loubov V. Umnova, Georgiu N. Vorozhcsov

Author Affiliations +

Proceedings Volume 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII; (2004) https://doi.org/10.1117/12.537787
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) and fluorescent diagnostics (FD) with Radaclorine (RadaPharma, Russia) (RC) have been provided in 32 patients with T1-4 stage basal cell carcinoma (BCC) and in 81 patients with Photsense. Pharmacocynetic studies with detecting the borders of tumor growth and intensity of accumulation of photosensizers in tumor, normal tissues and visualization have been done by Spectral-fluorescent Complex and spectranalyser LESA-01 (He-Ne-laser, λ=633nm). We've got fluorescence of all tumors and additional fluorescence zones were found, cytological verification of BCC was got in most of cases. The fluorescent signs of RC in normal skin were found till 5 days after injection. As a source of light for PDT we used simeconductive lasers: Milon - λ = 660+2nm, light dose was 200-300 J/cm² and Biospec (λ+672+2nm), multiple laser surface and interstitial irradiation was performed 24 hours after PS injection with total light dose till 400-600 J/cm². 2 months after PDT with RC complete response (CR) in 65.6% of cases, partial response-in 34.4% of cases. The efficacy of PDT with PS was higher (CR-84.0%, PR-14.8%). Our experience show pronounced efficacy of PDT with RC for BCC without side effects and very short skin toxicity.

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Elena G. Vakulovskaya M.D., Yuriy V. Kemov, Igor D. Zalevsky, Andrew V. Reshetnikov, Loubov V. Umnova, and Georgiu N. Vorozhcsov "Photodynamic therapy and fluorescent diagnostics of skin cancer with radochlorine and photosense: comparing efficacy and toxicity", Proc. SPIE 5315, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIII, (14 June 2004); https://doi.org/10.1117/12.537787

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