In vivo OCT study of neoplastic alterations of the oral cavity mucosa

Julia Valer'evna Fomina; Natalia D. Gladkova; Ludmila B. Snopova; Natalia M. Shakhova; Felix I. Feldchtein; Alexey V. Myakov

doi:10.1117/12.530412

1 July 2004 In vivo OCT study of neoplastic alterations of the oral cavity mucosa

Julia Valer'evna Fomina, Natalia D. Gladkova, Ludmila B. Snopova, Natalia M. Shakhova, Felix I. Feldchtein, Alexey V. Myakov

Author Affiliations +

Proceedings Volume 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII; (2004) https://doi.org/10.1117/12.530412
Event: Biomedical Optics 2004, 2004, San Jose, CA, United States

Abstract

The goal of our study was to conduct a statistical evaluation of the ability of optical coherence tomography (OCT) to detect neoplasia in vivo in oral cavity. The study enrolled 97 patients (35 volunteers with healthy mucosa of the oral cavity-group I, 41 patients with benign conditions-group II, 21 patients with dysplasia or carcinoma-group III). The diagnosis was established by a histopathology examination of biopsy material. Each biopsy site was imaged by OCT beforehand. Sensitivity of 83% and specificity of 98% were observed as a result of OCT image recognition of dysplastic/malignant versus benign/reactive conditions in the oral cavity. The interobserver agreement kappa was 0.76. Such sensitivity and specificity makes OCT a promising tool for non-invasive evaluation of tissue sites suspicious for high-grade dysplasia and cancer.

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Julia Valer'evna Fomina, Natalia D. Gladkova, Ludmila B. Snopova, Natalia M. Shakhova, Felix I. Feldchtein, and Alexey V. Myakov "In vivo OCT study of neoplastic alterations of the oral cavity mucosa", Proc. SPIE 5316, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine VIII, (1 July 2004); https://doi.org/10.1117/12.530412

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