Flexible coupling of a waveguide detector with a microscale field flow fractionation device

Himanshu J. Sant; Bruce K. Gale

doi:10.1117/12.529377

23 December 2003 Flexible coupling of a waveguide detector with a microscale field flow fractionation device

Himanshu J. Sant, Bruce K. Gale

Proceedings Volume 5345, Microfluidics, BioMEMS, and Medical Microsystems II; (2003) https://doi.org/10.1117/12.529377
Event: Micromachining and Microfabrication, 2004, San Jose, California, United States

Abstract

This paper describes a simple packaging method to fabricate microfluidic channels and obtain an optical detection interface for micro analysis systems. Specifically, this work reports on efforts to develop new methods for simple, fast and reliable design and fabrication of microscale field flow fractionation (FFF) based biological analysis systems. This modular detector interface results in a 38 nl detection region. Detector characterization is carried out to evaluate important figures of merit such as sensitivity, S/N ratio, and limit of detection. Plate height, a primary performance criterion for field flow fractionation is determined and compared with an on-chip detector. The developed system allow for a plug-and-play approach to the optical interface has resulted in flexibility in operation and increased robustness of the micro device.

Citation Download Citation

Himanshu J. Sant and Bruce K. Gale "Flexible coupling of a waveguide detector with a microscale field flow fractionation device", Proc. SPIE 5345, Microfluidics, BioMEMS, and Medical Microsystems II, (23 December 2003); https://doi.org/10.1117/12.529377

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available