Light-drive biomedical micro-tools and biochemical IC chips fabricated by 3D micro/nano stereolithography

Koji Ikuta; Shoji Maruo; Tadahiro Hasegawa; Suenobu Itho; Hayato Korogi; Atsushi Takahashi

doi:10.1117/12.581900

25 October 2004 Light-drive biomedical micro-tools and biochemical IC chips fabricated by 3D micro/nano stereolithography

Koji Ikuta, Shoji Maruo, Tadahiro Hasegawa, Suenobu Itho, Hayato Korogi, Atsushi Takahashi

Author Affiliations +

Proceedings Volume 5604, Optomechatronic Micro/Nano Components, Devices, and Systems; (2004) https://doi.org/10.1117/12.581900
Event: Optics East, 2004, Philadelphia, Pennsylvania, United States

Abstract

New concept of micro/nano tools working in water solutuon has been proposed by the author. A real three dimensional micro fabrication process using photo curable polymer named "micro/nano stereolithography" has been also developed by the author's group. The latest version of this process achieved 100 nm in 3D resolution and freely movable micro/nano mechanism are easily fabricated within 20 min. Nano tweezers and nano needle with two degrees of freedom were successfully fabricated without any assembly process. Cell and delicate biological materials can be remotely handled with neither any micro actuators nor lead wire. It was verified that this light-driven micro tool has precise force control with 10 FtN. These light-driven micro tools contribute to cellular biology as well as medical tools. The second application of microstereolithography is the biochemical IC chips for both micro chemical analysis and synthesis. Unlike conventional "lab. on a chip" and "micro total analysis system" (micro-TAS), our biochemical IC has micro pumps and active valves in one chip. Users can construct their own micro chemical device by themselves. The advanced biochemical IC chip-set for "on chip cell-free protein synthesis" has been prototyped and verified experimentally. A luminous enzyme of fire fly so called "Luciferase" and useful bio-marker protein "GFP" were synthesized successfully. According to above results, the biomchemical IC chips will be useful to "Order-made medicine" in near future.

Citation Download Citation

Koji Ikuta, Shoji Maruo, Tadahiro Hasegawa, Suenobu Itho, Hayato Korogi, and Atsushi Takahashi "Light-drive biomedical micro-tools and biochemical IC chips fabricated by 3D micro/nano stereolithography", Proc. SPIE 5604, Optomechatronic Micro/Nano Components, Devices, and Systems, (25 October 2004); https://doi.org/10.1117/12.581900

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