Preclinical evaluation of zinc phthalocyanine tetrasulfonate-based PDT

Antonella Borgatti-Jeffreys; Stephen B. Hooser; Margaret A. Miller; Rose M. Thomas; Amalia deGortari; Michael D. Lucroy D.V.M.

doi:10.1117/12.588378

25 April 2005 Preclinical evaluation of zinc phthalocyanine tetrasulfonate-based PDT

Antonella Borgatti-Jeffreys, Stephen B. Hooser, Margaret A. Miller, Rose M. Thomas, Amalia deGortari, Michael D. Lucroy D.V.M.

Author Affiliations +

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.588378
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Photodynamic therapy (PDT) involves the light activation of a drug within a tumor causing selective tumor cell death. Unfortunately, some photosensitizing drugs have been associated with adverse reactions in veterinary patients. Zinc phthalocyanine tetrasulfonate (ZnPcS₄) is a promising second-generation photosensitizer for use in veterinary medicine, however, it cannot be applied clinically until safety and efficacy data are available. ZnPcS₄ was given to Swiss Webster mice to assess acute toxicity. Doses >100 mg/kg were associated with acute toxicity and mortality, and doses >100 mg/kg resulted in renal tubular nephrosis, suggesting that the minimum toxic dose is approximately 100 mg/kg. Based on these data, a Phase I clinical trial of ZnPcS4-based PDT in tumor-bearing dogs is underway, with ZnPcS₄ doses up to 2 mg/kg producing no apparent toxicity. Tumor response has been observed after ZnPcS₄-based PDT using doses as low as 0.25 mg/kg, suggesting that conventional phase I clinical trials may not be appropriate for PDT protocols.

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Antonella Borgatti-Jeffreys, Stephen B. Hooser, Margaret A. Miller, Rose M. Thomas, Amalia deGortari, and Michael D. Lucroy D.V.M. "Preclinical evaluation of zinc phthalocyanine tetrasulfonate-based PDT", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.588378

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