Diode laser monitor for singlet molecular oxygen

Seonkyung Lee; Leyun Zhu; Ahmed Minhaj; Michael F. Hinds; A. A. Ferrante; D. H. Vu; David Rosen; Steven J. Davis; Tayyaba Hasan

doi:10.1117/12.589347

8 April 2005 Diode laser monitor for singlet molecular oxygen

Seonkyung Lee, Leyun Zhu, Ahmed Minhaj, Michael F. Hinds, A. A. Ferrante, D. H. Vu, David Rosen, Steven J. Davis, Tayyaba Hasan

Author Affiliations +

Proceedings Volume 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV; (2005) https://doi.org/10.1117/12.589347
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Monitoring singlet molecular oxygen (¹O₂) produced by photodynamic therapy (PDT) can lead more precise and effective cancer treatment. Physical Sciences Inc. (PSI) has developed a singlet oxygen monitor based on a pulsed diode laser technology. In this paper, we present results of singlet oxygen detection in the solution phase and in a rat prostate cancer cell line, as well as PDT mechanism modeling. We describe an improved detection approach for singlet oxygen monitoring that employs a fiber-coupled optical set-up and fast data acquisition system.

Citation Download Citation

Seonkyung Lee, Leyun Zhu, Ahmed Minhaj, Michael F. Hinds, A. A. Ferrante, D. H. Vu, David Rosen, Steven J. Davis, and Tayyaba Hasan "Diode laser monitor for singlet molecular oxygen", Proc. SPIE 5689, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XIV, (8 April 2005); https://doi.org/10.1117/12.589347

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