Design and fabrication of disposable percutaneous chemical sensors

Kuo-Chih Liao; Thieo Hogen-Esch; Frances J. Richmond; Laura Marcu; Gerald E. Loeb

doi:10.1117/12.587668

23 March 2005 Design and fabrication of disposable percutaneous chemical sensors

Kuo-Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, Gerald E. Loeb

Proceedings Volume 5691, Optical Fibers and Sensors for Medical Applications V; (2005) https://doi.org/10.1117/12.587668
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Sencils (sensory cilia) are chemical sensors that are minimally invasive, disposable and easily readable to make frequent measurements of various analytes in vivo over a period of 1-3 months. A percutaneous optical fiber permits precise, reliable photonic measurement of chemical reactions in a nano-engineered polymer matrix attached to the internal end of the fiber. The first Sencils sense interstitial glucose based on measurement of fluorescence resonance energy transfer (FRET) between fluorophors bound to dextran and Concanavalin-A in a polyethylene glycol (PEG) matrix. In vitro experiments demonstrate a rapid and precise relationship between the ratio of the two fluorescent emissions and concentration of glucose in saline over the physiological range of 0-500mg/dl. Chronic implantation in pigs has demonstrated biocompatibility. The Sencil platform can be adapted to detect other analytes in interstitial fluids.

Citation Download Citation

Kuo-Chih Liao, Thieo Hogen-Esch, Frances J. Richmond, Laura Marcu, and Gerald E. Loeb "Design and fabrication of disposable percutaneous chemical sensors", Proc. SPIE 5691, Optical Fibers and Sensors for Medical Applications V, (23 March 2005); https://doi.org/10.1117/12.587668

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available