Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot-micelles

Hongyou Fan; Erik W. Leve; Chessa Scullin; David Tallant; Michael C. Wilson; C. Jeffrey Brinker

doi:10.1117/12.601511

28 April 2005 Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot-micelles

Hongyou Fan, Erik W. Leve, Chessa Scullin, David Tallant, Michael C. Wilson, C. Jeffrey Brinker

Proceedings Volume 5705, Nanobiophotonics and Biomedical Applications II; (2005) https://doi.org/10.1117/12.601511
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

We report a simple and rapid method to synthesize water-soluble and biocompatible fluorescent quantum dot (QD)-micelles by encapsulation of monodisperse, hydrophobic QDs inside surfactant/lipid micelles. Analysis of UV-vis spectra, transmission electron microscopy, and photo luminescence spectra indicate that the water-soluble semiconductor QD-micelles are monodisperse and retain the optical properties of the original hydrophobic QDs. The QD-micelles were shown to be biocompatible and exhibited little or no aggregation when taken up by cultured rat hippocampal neurons.

Citation Download Citation

Hongyou Fan, Erik W. Leve, Chessa Scullin, David Tallant, Michael C. Wilson, and C. Jeffrey Brinker "Surfactant-assisted synthesis of water-soluble and biocompatible semiconductor quantum dot-micelles", Proc. SPIE 5705, Nanobiophotonics and Biomedical Applications II, (28 April 2005); https://doi.org/10.1117/12.601511

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