X-ray dark-field imaging and potential of its clinical application

Daisuke Shimao; Hiroshi Sugiyama; Toshiyuki Kunisada M.D.; Anton Maksimenko; Fukai Toyofuku; Ei Ueno M.D.; Katsuhito Yamasaki; Chiho Obayashi; Kazuyuki Hyodo; Gang Li; Lin Pan; Xiaoming Jiang; Masami Ando

doi:10.1117/12.595021

20 April 2005 X-ray dark-field imaging and potential of its clinical application

Daisuke Shimao, Hiroshi Sugiyama, Toshiyuki Kunisada M.D., Anton Maksimenko, Fukai Toyofuku, Ei Ueno M.D., Katsuhito Yamasaki, Chiho Obayashi, Kazuyuki Hyodo, Gang Li, Lin Pan, Xiaoming Jiang, Masami Ando

Author Affiliations +

Proceedings Volume 5745, Medical Imaging 2005: Physics of Medical Imaging; (2005) https://doi.org/10.1117/12.595021
Event: Medical Imaging, 2005, San Diego, California, United States

Abstract

X-ray dark-field imaging (DFI) due to refraction is under development with intension of its clinical application. In this system we have adopted an asymmetric-cut monochro-collimator (M) and an angular analyzer (A) of Si 440 diffraction at 35 keV of X-rays. By choosing an appropriate thickness T of A that satisfies the condition T = ΛN where Λ is the extinction distance and N integer the transmissivity in the region of |W| (angular parameter) < 1 should be theoretically almost zero and |W| > 1 should be approximately 70-80%. This has been experimentally proven. Under this condition the X-rays whose propagation direction may not change such as those receiving only absorption will not go into the forward diffraction direction after A but go into the diffraction direction, while the X-rays refracted by object may go into the forward diffraction direction after A. We have settled two targets of clinical views: soft tissues at joints and early check of breast cancer. A first clear image of articular cartilage of small joint was successfully obtained using a proximal interphalangeal joint that was amputated from a cadaver. Since larger view field is needed for clinical use the size of approximately 90 mm in square has been successfully achieved. Using this beam articular cartilage of knee and shoulder joints from the same cadaver have been successfully visualized. Further visibility test by the DFI is under way for a phantom of breast cancer, paraffin fixed sliced breast samples containing micro-calcification, tumor and excised breast tissue.

Citation Download Citation

Daisuke Shimao, Hiroshi Sugiyama, Toshiyuki Kunisada M.D., Anton Maksimenko, Fukai Toyofuku, Ei Ueno M.D., Katsuhito Yamasaki, Chiho Obayashi, Kazuyuki Hyodo, Gang Li, Lin Pan, Xiaoming Jiang, and Masami Ando "X-ray dark-field imaging and potential of its clinical application", Proc. SPIE 5745, Medical Imaging 2005: Physics of Medical Imaging, (20 April 2005); https://doi.org/10.1117/12.595021

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
8 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

X-rays

X-ray imaging

Cartilage

Absorption

Diffraction

Tissues

Breast cancer

Show All Keywords

Keywords/Phrases

Search In:

Publication Years