Using optical tweezers to examine the chemotactic force to a single inflammatory cell-eosinophil stimulated by chemoattractants prepared from Toxocara Canis larvae

Po-Chen Shih; Yi-Jr Su; Ke-Min Chen; Lin-Ni Jen; Cheng-tzu Liu; Long Hsu

doi:10.1117/12.616826

26 August 2005 Using optical tweezers to examine the chemotactic force to a single inflammatory cell--eosinophil stimulated by chemoattractants prepared from Toxocara Canis larvae

Po-Chen Shih, Yi-Jr Su, Ke-Min Chen, Lin-Ni Jen, Cheng-tzu Liu, Long Hsu

Author Affiliations +

Proceedings Volume 5930, Optical Trapping and Optical Micromanipulation II; 59301R (2005) https://doi.org/10.1117/12.616826
Event: Optics and Photonics 2005, 2005, San Diego, California, United States

Abstract

Granulocytes are a group of white blood cells belonging to the innate immune system in human and in murine in which eosinophils play an important role in worm infection-induced inflammation. The migration of these cells is well characterized and has been separated into four steps: rolling, adhesion, transendothelial migration, and chemotaxis, however, the physical characteristics of the chemotactic force to eosinophils from worm component remain largely unknown. Note that optical tweezers are featured in the manipulation of a single cell and the measurement of biological forces. Therefore, we propose to use optical tweezers to examine the chemotactic force to a eosinophil from a T. canis lavae preparation in terms of distance during the migration of eosinophil.

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Po-Chen Shih, Yi-Jr Su, Ke-Min Chen, Lin-Ni Jen, Cheng-tzu Liu, and Long Hsu "Using optical tweezers to examine the chemotactic force to a single inflammatory cell--eosinophil stimulated by chemoattractants prepared from Toxocara Canis larvae", Proc. SPIE 5930, Optical Trapping and Optical Micromanipulation II, 59301R (26 August 2005); https://doi.org/10.1117/12.616826

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