Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics

I. G. Meerovich; Z. S. Smirnova; N. A. Oborotova; E. A. Lukyanets; G. A. Meerovich; V. M. Derkacheva; A. P. Polozkova; I. Yu. Kubasova; A. Yu. Baryshnikov

doi:10.1117/12.640120

7 December 2006 Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics

I. G. Meerovich, Z. S. Smirnova, N. A. Oborotova, E. A. Lukyanets, G. A. Meerovich, V. M. Derkacheva, A. P. Polozkova, I. Yu. Kubasova, A. Yu. Baryshnikov

Author Affiliations +

Proceedings Volume 5973, Current Research on Laser Use in Oncology: 2000-2004; 59730I (2006) https://doi.org/10.1117/12.640120
Event: Current Research on Laser Use in Oncology: 2000-2004, 2004, Moscow, Russian Federation

Abstract

This work is devoted to investigation of possibility to use the liposomal form of aluminium hydroxide tetra-3-phenylthiophthalocyanine as photosensitizer of near-infrared range. Aluminium hydroxide tetra-3-phenylthiophthalocyanine has shown high selectivity of accumulation in tumor comparing to normal tissue of mice as well as high photodynamic efficiency on mice bearing Erlich tumor (ELD) and lympholeucosis P-388. This compozition can be used to develop new effective photosensitizer for photodynamic therapy and fluorescent diagnostics.

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I. G. Meerovich, Z. S. Smirnova, N. A. Oborotova, E. A. Lukyanets, G. A. Meerovich, V. M. Derkacheva, A. P. Polozkova, I. Yu. Kubasova, and A. Yu. Baryshnikov "Aluminium hydroxide tetra-3-phenylthiophthalocyanine as new photosensitizer for photodynamic therapy and fluorescent diagnostics", Proc. SPIE 5973, Current Research on Laser Use in Oncology: 2000-2004, 59730I (7 December 2006); https://doi.org/10.1117/12.640120

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