Cone beam computed tomography angiogenesis imaging: preliminary studies

David Conover; Ruola Ning; Scott Paoni; Ian Wilson M.D.; Xianghua Lu; Yan Zhang; Bruce Fenton

doi:10.1117/12.655655

13 March 2006 Cone beam computed tomography angiogenesis imaging: preliminary studies

David Conover, Ruola Ning, Scott Paoni, Ian Wilson M.D., Xianghua Lu, Yan Zhang, Bruce Fenton

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61433G (2006) https://doi.org/10.1117/12.655655
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

The purpose of this study is to demonstrate the feasibility of performing cone beam CT angiogenesis imaging (CBCTAI) using a cone beam CT scanner prototype. We have developed a cone beam breast CT imaging technique that is able to detect a ~2 mm tumor in live mice and have expanded the imaging to include visualization of tumor vessels. The CBCT prototype consisted of a modified clinical CT scanner and a flat panel detector. This CBCT scanner prototype was used for a series of preliminary contrast studies with live mice: contrast-to-scan time delay, contrast for tumor vessel enhancement (comparison with histology) and early tumor vessel development imaging. The results of the live mice studies demonstrate that good image quality can be achieved with this prototype demonstrating the feasibility of CBCTAI. Achieving the CBCTAI technique on the cone beam breast CT imaging modality will significantly advance breast cancer detection, diagnosis and treatment.

Citation Download Citation

David Conover, Ruola Ning, Scott Paoni, Ian Wilson M.D., Xianghua Lu, Yan Zhang, and Bruce Fenton "Cone beam computed tomography angiogenesis imaging: preliminary studies", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61433G (13 March 2006); https://doi.org/10.1117/12.655655

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