Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice

Baowei Fei; Hesheng Wang; Raymond F. Muzic Jr.; Chris A. Flask; Denise Feyes; David L. Wilson; Jeffrey L. Duerk; Nancy L. Oleinick

doi:10.1117/12.649531

13 March 2006 Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice

Baowei Fei, Hesheng Wang, Raymond F. Muzic Jr., Chris A. Flask, Denise Feyes, David L. Wilson, Jeffrey L. Duerk, Nancy L. Oleinick

Author Affiliations +

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61433I (2006) https://doi.org/10.1117/12.649531
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

We are investigating imaging techniques to study the tumor response to photodynamic therapy (PDT). PET can provide physiological and functional information. High-resolution MRI can provide anatomical and morphological changes. Image registration can combine MRI and PET images for improved tumor monitoring. In this study, we acquired high-resolution MRI and microPET [¹⁸F]fluorodeoxyglucose (FDG) images from C3H mice with RIF-1 tumors that were treated with Pc 4-based PDT. For tumor registration, we developed a finite element model (FEM)-based deformable registration scheme. To assess the registration quality, we performed slice by slice review of both image volumes, computed the volume overlap ratios, and visualized both volumes in color overlay. The mean volume overlap ratios for tumors were 94.7% after registration. Registration of high-resolution MRI and microPET images combines anatomical and functional information of the tumors and provides a useful tool for evaluating photodynamic therapy.

Citation Download Citation

Baowei Fei, Hesheng Wang, Raymond F. Muzic Jr., Chris A. Flask, Denise Feyes, David L. Wilson, Jeffrey L. Duerk, and Nancy L. Oleinick "Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61433I (13 March 2006); https://doi.org/10.1117/12.649531

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available