Wound dressings and other types of wound healing technologies are experiencing fast-paced development and rapid
growth. As the population ages, demand will continue to rise for advanced dressings used to treat chronic wounds, such
as pressure ulcers, venous stasis ulcers, and diabetic ulcers. Moist wound dressings, which facilitate natural wound
healing in a cost-effective manner, will be increasingly important.
In commercially available hydrogel / gauze wound dressings the gel swells to adsorb wound excreta and provide an
efficient non adhesive particle barrier. An alternative to hydrogels are microgels. Essentially discrete colloidal gel
particles, as a result of their very high surface area to volume ratio compared to bulk gels, they have a much faster
response to external stimuli such as temperature or pH. In response to either an increase or decrease in solvent quality
these porous networks shrink and swell reversibly. When swollen the interstitial regions within the polymer matrix are
available for further chemistry; such as the incorporation of small molecules. The reversible shrinking and swelling as a
function of external stimuli provides a novel drug release system. As the environmental conditions of a wound change
over its lifetime, tending to increase in pH if there is an infection combining these discrete polymeric particles with a
substrate such as cotton, results in a smart wound dressing.
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