Fluctuations in a coupled-oscillator model of the cardiovascular system

Jorge A. González; Jose J. Suárez-Vargas; Aneta Stefanovska; Peter V. E. McClintock

doi:10.1117/12.724718

21 June 2007 Fluctuations in a coupled-oscillator model of the cardiovascular system

Jorge A. González, Jose J. Suárez-Vargas, Aneta Stefanovska, Peter V. E. McClintock

Proceedings Volume 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems; 66020Y (2007) https://doi.org/10.1117/12.724718
Event: SPIE Fourth International Symposium on Fluctuations and Noise, 2007, Florence, Italy

Abstract

We present a model of the cardiovascular system (CVS) based on a system of coupled oscillators. Using this approach we can describe several complex physiological phenomena that can have a range of applications. For instance, heart rate variability (HRV), can have a new deterministic explanation. The intrinsic dynamics of the HRV is controlled by deterministic couplings between the physiological oscillators in our model and without the need to introduce external noise as is commonly done. This new result provides potential applications not only for physiological systems but also for the design of very precise electronic generators where the frequency stability is crucial. Another important phenomenon is that of oscillation death. We show that in our CVS model the mechanism leading to the quenching of the oscillations can be controlled, not only by the coupling parameter, but by a more general scheme. In fact, we propose that a change in the relative current state of the cardiovascular oscillators can lead to a cease of the oscillations without actually changing the strength of the coupling among them. We performed real experiments using electronic oscillators and show them to match the theoretical and numerical predictions. We discuss the relevance of the studied phenomena to real cardiovascular systems regimes, including the explanation of certain pathologies, and the possible applications in medical practice.

Citation Download Citation

Jorge A. González, Jose J. Suárez-Vargas, Aneta Stefanovska, and Peter V. E. McClintock "Fluctuations in a coupled-oscillator model of the cardiovascular system", Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020Y (21 June 2007); https://doi.org/10.1117/12.724718

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