Label-free single-molecule all-optical sensor

Andrea M. Armani; Scott E. Fraser; Richard C. Flagan

doi:10.1117/12.761007

7 February 2008 Label-free single-molecule all-optical sensor

Andrea M. Armani, Scott E. Fraser, Richard C. Flagan

Proceedings Volume 6852, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII; 68520A (2008) https://doi.org/10.1117/12.761007
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

Recently, quality factors greater than 100 million were demonstrated using planar arrays of silica microtoroid resonators. These high Q factors allow the toroidal resonators to perform very sensitive detection experiments. By functionalizing the silica surface of the toroid with biotin, the toroidal resonators become both specific and sensitive detectors for Streptavidin. One application of this sensor is performing detection in lysates. To mimic this type of environment, additional solutions of Streptavidin were prepared which also contained high concentrations (nM and μM) of tryptophan.

Citation Download Citation

Andrea M. Armani, Scott E. Fraser, and Richard C. Flagan "Label-free single-molecule all-optical sensor", Proc. SPIE 6852, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII, 68520A (7 February 2008); https://doi.org/10.1117/12.761007

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