Specular reflection vs. backscattering for transdermal OCT-based glucose monitoring with an implantable sensor system

Alexander I. Kholodnykh; Ralph Ballerstadt; Adam Boretsky; Colton Evans; Ashok Gowda; Roger McNichols; Massoud Motamedi

doi:10.1117/12.763563

28 February 2008 Specular reflection vs. backscattering for transdermal OCT-based glucose monitoring with an implantable sensor system

Alexander I. Kholodnykh, Ralph Ballerstadt, Adam Boretsky, Colton Evans, Ashok Gowda, Roger McNichols, Massoud Motamedi

Author Affiliations +

Proceedings Volume 6863, Optical Diagnostics and Sensing VIII; 686306 (2008) https://doi.org/10.1117/12.763563
Event: SPIE BiOS, 2008, San Jose, California, United States

Abstract

The reliability of optical techniques for non-invasive monitoring of glucose can be significantly improved by the deployment of a subcutaneous implantable sensor that can closely track the changes in the local concentration of glucose in skin. We have developed a novel implantable sensor that can track glucose-induced changes in the optical turbidity of the implant. In this sensor, optical turbidity decreases significantly with increased glucose concentrations. We performed comparative measurements by optical coherence tomography (OCT) used to monitor backscattering or specular reflection originated from specific structures within the sensor and by collimated light transmission measurement technique to measure the changes in light attenuation as function of glucose concentration within the sensor as well as when the sensor was implanted in phantom media or in tissue samples. These measurements showed that glucose-induced changes in the transmission values derived from OCT monitoring of the sensor turbidity differed up two times from those obtained by collimated transparency measurement (CTM) technique. These results were used to determine the values for scattering coefficients of tissue and the sensor and to estimate the relative loss in sensor sensitivity as a function of implantation depth in tissue. The results suggest that the implantable sensor can be placed in turbid medium such as skin up to an optical depth of 12 mean free paths (mfp), one could expect. For a turbid medium such as skin with a scattering coefficient (µs ) of 10mm-1, this would result in geometrical depth of implantation at 1.2 mm beneath the tissue where sensor sensitivity of 50% or higher is expected. The study demonstrates that it could be feasible to engineer a novel optical sensor for glucose monitoring that can be implanted under the skin while providing a high degree of sensitivity and specificity for non-invasive glucose monitoring.

Citation Download Citation

Alexander I. Kholodnykh, Ralph Ballerstadt, Adam Boretsky, Colton Evans, Ashok Gowda, Roger McNichols, and Massoud Motamedi "Specular reflection vs. backscattering for transdermal OCT-based glucose monitoring with an implantable sensor system", Proc. SPIE 6863, Optical Diagnostics and Sensing VIII, 686306 (28 February 2008); https://doi.org/10.1117/12.763563

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $17.00

Non-members: $21.00 ADD TO CART

PROCEEDINGS
12 PAGES

DOWNLOAD PAPER SAVE TO MY LIBRARY

GET CITATION

RIGHTS & PERMISSIONS

Get copyright permission Get copyright permission on Copyright Marketplace

KEYWORDS

Sensors

Optical coherence tomography

Glucose

Signal attenuation

Tissues

Tissue optics

Skin

Show All Keywords

Keywords/Phrases

Search In:

Publication Years